SOTAVerified

Protein Design

Formally, given the design requirements of users, models are required to generate protein amino acid sequences that align with those requirements.

Papers

Showing 76100 of 175 papers

TitleStatusHype
RNAFlow: RNA Structure & Sequence Design via Inverse Folding-Based Flow MatchingCode2
UniIF: Unified Molecule Inverse Folding0
Implicitly Guided Design with PropEn: Match your Data to Follow the Gradient0
Learning the Language of Protein StructureCode1
Out of Many, One: Designing and Scaffolding Proteins at the Scale of the Structural Universe with Genie 2Code2
SurfPro: Functional Protein Design Based on Continuous Surface0
Model-based reinforcement learning for protein backbone design0
ProteinEngine: Empower LLM with Domain Knowledge for Protein Engineering0
Annotation-guided Protein Design with Multi-Level Domain Alignment0
Using GANs for De Novo Protein Design Targeting Microglial IL-3Rα to Inhibit Alzheimer's Progression0
Diffusion on language model encodings for protein sequence generation0
TaxDiff: Taxonomic-Guided Diffusion Model for Protein Sequence GenerationCode3
Generative AI for Controllable Protein Sequence Design: A Survey0
X-LoRA: Mixture of Low-Rank Adapter Experts, a Flexible Framework for Large Language Models with Applications in Protein Mechanics and Molecular DesignCode3
Generative Adversarial Model-Based Optimization via Source Critic RegularizationCode0
Learning immune receptor representations with protein language models0
Enhancing the efficiency of protein language models with minimal wet-lab data through few-shot learning0
ProtAgents: Protein discovery via large language model multi-agent collaborations combining physics and machine learningCode1
Improved motif-scaffolding with SE(3) flow matchingCode3
A framework for conditional diffusion modelling with applications in motif scaffolding for protein design0
Progressive Multi-Modality Learning for Inverse Protein FoldingCode1
Fast non-autoregressive inverse folding with discrete diffusionCode1
PDB-Struct: A Comprehensive Benchmark for Structure-based Protein DesignCode0
AI-predicted protein deformation encodes energy landscape0
De novo protein design using geometric vector field networksCode1
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Benchmark Results

#ModelMetricClaimedVerifiedStatus
1GraphTransPerplexity6.63Unverified
2StructGNNPerplexity6.4Unverified
3AlphaDesignPerplexity6.3Unverified
4GCAPerplexity6.05Unverified
5GVPPerplexity5.36Unverified
6ProteinMPNNPerplexity4.61Unverified
7PiFoldPerplexity4.55Unverified
8Knowledge-DesignPerplexity3.46Unverified
#ModelMetricClaimedVerifiedStatus
1ESM-IFPerplexity6.44Unverified
2GVP-largePerplexity6.17Unverified