The construction of ceRNAs network reveals the prognostic characteristics of prostate cancer

Abstract

The dysregulation of transcripts is characterized as one of the main mechanisms in tumor pathogenesis. The recent discovery developed a new hypothesis, competitive endogenous RNAs (ceRNAs), which could regulate other RNA transcripts via competing for their shared miRNAs. The interaction of elements in ceRNAs network was involved in a large range of biological reactions and facilitate to cancer progression. In this study, we performed a comprehensive investigation on the regulatory mechanisms and functional roles of ceRNAs in prostate cancer (PCa) and constructed a ceRNAs network which could possess potential value in patient prognosis and be evaluated as therapeutic targets for PCa.

Tasks

Reproductions