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Missing and spurious interaction in additive, multiplicative and odds ratio models

2017-12-12Unverified0· sign in to hype

Jorge Fernandez-de-Cossio, Jorge Fernandez-de-Cossio-Diaz, Toshifumi Takao, Yasser Perera

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Abstract

Additive, multiplicative, and odd ratio neutral models for interactions are for long advocated and controversial in epidemiology. We show here that these commonly advocated models are biased, leading to spurious interactions, and missing true interactions.

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