Introducing π-HelixNovo for practical large-scale de novo peptide sequencing
2023-08-27bioRxiv 2023Code Available1· sign in to hype
Tingpeng Yang, Tianze Ling, Boyan Sun, Zhendong Liang, Fan Xu, Xiansong Huang, Linhai Xie, Yonghong He, Leyuan Li, Fuchu He, Yu Wang, Cheng Chang
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ReproduceCode
- github.com/PHOENIXcenter/pi-HelixNovoOfficialpytorch★ 14
Abstract
De novo peptide sequencing is a promising approach for novel peptide discovery. We use a novel concept of complementary spectra to enhance ion information and propose a de novo sequencing model π-HelixNovo based on Transformer architecture. π-HelixNovo outperforms other state-of-the-art models and enhances the taxonomic resolution of gut metaproteome, taking a significant step forward in de novo sequencing.