Dynamical Origin for Winner-Take-All Competition in A Biological Network of The Hippocampal Dentate Gyrus

Abstract

We consider a biological network of the hippocampal dentate gyrus (DG). The DG is a pre-processor for pattern separation which facilitates pattern storage and retrieval in the CA3 area of the hippocampus. The main encoding cells in the DG are the granule cells (GCs) which receive the input from the entorhinal cortex (EC) and send their output to the CA3. The activation degree of GCs is so low (~ 5%). This sparsity has been thought to enhance the pattern separation. We investigate the dynamical origin for winner-take-all (WTA) competition which leads to sparse activation of the GCs. The whole GCs are grouped into lamellar clusters. In each GC cluster, there is one inhibitory (I) basket cell (BC) along with excitatory (E) GCs. There are three kinds of external inputs into the GCs; the direct excitatory EC input, the indirect inhibitory EC input, mediated by the HIPP (hilar perforant path-associated) cells, and the excitatory input from the hilar mossy cells (MCs). The firing activities of the GCs are determined via competition between the external E and I inputs. The E-I conductance ratio R_ E-I^ (con)* (given by the time average of the external E to I conductances) may represents well the degree of such external E-I input competition. GCs become active when their R_ E-I^ (con)* is larger than a threshold R_th^*, and then the mean firing rates of the active GCs are strongly correlated with R_ E-I^ (con)*. In each GC cluster, the feedback inhibition of the BC may select the winner GCs. GCs with larger R_ E-I^ (con)* than the threshold R_th^* survive, and they become winners; all the other GCs with smaller R_ E-I^ (con)* become silent. The WTA competition occurs via competition between the firing activity of the GCs and the feedback inhibition from the BC in each GC cluster.

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