Deeplasia: deep learning for bone age assessment validated on skeletal dysplasias
Sebastian Rassmann, Alexandra Keller, Kyra Skaf, Alexander Hustinx, Ruth Gausche, Miguel A. Ibarra-Arrelano, Tzung-Chien Hsieh, Yolande E. D. Madajieu, Markus M. Nöthen, Roland Pfäffle, Ulrike I. Attenberger, Mark Born, Klaus Mohnike, Peter M. Krawitz & Behnam Javanmardi
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Abstract
Skeletal dysplasias collectively affect a large number of patients worldwide. Most of these disorders cause growth anomalies. Hence, evaluating skeletal maturity via the determination of bone age (BA) is a useful tool. Moreover, consecutive BA measurements are crucial for monitoring the growth of patients with such disorders, especially for timing hormonal treatment or orthopedic interventions. However, manual BA assessment is time-consuming and suffers from high intra- and inter-rater variability. This is further exacerbated by genetic disorders causing severe skeletal malformations. While numerous approaches to automate BA assessment have been proposed, few are validated for BA assessment on children with skeletal dysplasias.