BioTD: an online database of biotoxins
Gaoang Wang, Hang Wu, Yang Liao, Zhen Chen, Qing Zhou, Wenxing Wang, Yifei Liu, Yilin Wang, Meijing Wu, Ruiqi Xiang, Yuntao Yu, Xi Zhou, Feng Zhu, Zhonghua Liu, Tingjun Hou
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Biotoxins, mainly produced by venomous animals, plants and microorganisms, exhibit high physiological activity and unique effects such as lowering blood pressure and analgesia. A number of venom-derived drugs are already available on the market, with many more candidates currently undergoing clinical and laboratory studies. However, drug design resources related to biotoxins are insufficient, particularly a lack of accurate and extensive activity data. To fulfill this demand, we develop the Biotoxins Database (BioTD). BioTD is the largest open-source database for toxins, offering open access to 14,607 data records (8,185 activity records), covering 8,975 toxins sourced from 5,220 references and patents across over 900 species. The activity data in BioTD is categorized into five groups: Activity, Safety, Kinetics, Hemolysis and other physiological indicators. Moreover, BioTD provides data on 986 mutants, refines the whole sequence and signal peptide sequences of toxins, and annotates disulfide bond information. Given the importance of biotoxins and their associated data, this new database was expected to attract broad interests from diverse research fields in drug discovery. BioTD is freely accessible at http://biotoxin.net/.