Bioelectrical Interfaces Beyond Cellular Excitability: Cancer, Aging, and Gene Expression Reprogramming
Paolo Cadinu, Matthew Burgess, Catarina Franco Jones, Titouan Luciani, Marzia Iarossi, Manuel Schröter, Nako Nakatsuka, Mustafa B. A. Djamgoz, Gil Gonçalves, Paola Sanjuán-Alberte, Paula M. Mendes, Frankie J. Rawson, Malavika Nair, Michael Levin, Rosalia Moreddu
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Bioelectrical interfaces represent a significant evolution in the intersection of nanotechnology and biophysics, offering new strategies for probing and influencing cellular processes. These systems capitalize on the subtle but powerful electric fields within living matter, potentially enabling applications beyond cellular excitability, ranging from targeted cancer therapies to interventions in genetic mechanisms and aging. This perspective article envisions the translation, development and application of next-generation solid-state bioelectrical interfaces and their transformative impact across several critical areas of medical research.