Biochemical Prostate Cancer Recurrence Prediction: Thinking Fast & Slow
Suhang You, Sanyukta Adap, Siddhesh Thakur, Bhakti Baheti, Spyridon Bakas
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- github.com/yousuhang/IU-ComPath-LeoPardOfficialpytorch★ 3
Abstract
Time to biochemical recurrence in prostate cancer is essential for prognostic monitoring of the progression of patients after prostatectomy, which assesses the efficacy of the surgery. In this work, we proposed to leverage multiple instance learning through a two-stage ``thinking fast \& slow'' strategy for the time to recurrence (TTR) prediction. The first (``thinking fast'') stage finds the most relevant WSI area for biochemical recurrence and the second (``thinking slow'') stage leverages higher resolution patches to predict TTR. Our approach reveals a mean C-index (Ci) of 0.733 (=0.059) on our internal validation and Ci=0.603 on the LEOPARD challenge validation set. Post hoc attention visualization shows that the most attentive area contributes to the TTR prediction.