A new solution to the curved Ewald sphere problem for 3D image reconstruction in electron microscopy

Code

• gitlab.com/jpchen1/em-reconstruction-with-ewald
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Abstract

We develop an algorithm capable of imaging a three-dimensional object given a collection of two-dimensional images of that object that are significantly influenced by the curvature of the Ewald sphere. These two-dimensional images cannot be approximated as projections of the object. Such an algorithm is useful in cryo-electron microscopy where larger samples, higher resolution, or lower energy electron beams are desired, all of which contribute to the significance of Ewald curvature.

Tasks

Reproductions