Image-based Quantification of Postural Deviations on Patients with Cervical Dystonia: A Machine Learning Approach Using Synthetic Training Data
Roland Stenger, Sebastian Löns, Nele Brügge, Feline Hamami, Alexander Münchau, Theresa Paulus, Anne Weissbach, Tatiana Usnich, Max Borsche, Martje G. Pauly, Lara M. Lange, Markus A. Hobert, Rebecca Herzog, Ana Luísa de Almeida Marcelino, Tina Mainka, Friederike Schumann, Lukas L. Goede, Johanna Reimer, Julienne Haas, Jos Becktepe, Alexander Baumann, Robin Wolke, Chi Wang Ip, Thorsten Odorfer, Daniel Zeller, Lisa Harder-Rauschenberger, John-Ih Lee, Philipp Albrecht, Tristan Kölsche, Joachim K. Krauss, Johanna M. Nagel, Joachim Runge, Johanna Doll-Lee, Simone Zittel, Kai Grimm, Pawel Tacik, André Lee, Tobias Bäumer, Sebastian Fudickar
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Cervical dystonia (CD) is the most common form of dystonia, yet current assessment relies on subjective clinical rating scales, such as the Toronto Western Spasmodic Torticollis Rating Scale (TWSTRS), which requires expertise, is subjective and faces low inter-rater reliability some items of the score. To address the lack of established objective tools for monitoring disease severity and treatment response, this study validates an automated image-based head pose and shift estimation system for patients with CD. We developed an assessment tool that combines a pretrained head-pose estimation algorithm for rotational symptoms with a deep learning model trained exclusively on ~16,000 synthetic avatar images to evaluate rare translational symptoms, specifically lateral shift. This synthetic data approach overcomes the scarcity of clinical training examples. The system's performance was validated in a multicenter study by comparing its predicted scores against the consensus ratings of 20 clinical experts using a dataset of 100 real patient images and 100 labeled synthetic avatars. The automated system demonstrated strong agreement with expert clinical ratings for rotational symptoms, achieving high correlations for torticollis (r=0.91), laterocollis (r=0.81), and anteroretrocollis (r=0.78). For lateral shift, the tool achieved a moderate correlation (r=0.55) with clinical ratings and demonstrated higher accuracy than human raters in controlled benchmark tests on avatars. By leveraging synthetic training data to bridge the clinical data gap, this model successfully generalizes to real-world patients, providing a validated, objective tool for CD postural assessment that can enable standardized clinical decision-making and trial evaluation.