CRESTomics: Analyzing Carotid Plaques in the CREST-2 Trial with a New Additive Classification Model
Pranav Kulkarni, Brajesh K. Lal, Georges Jreij, Sai Vallamchetla, Langford Green, Jenifer Voeks, John Huston, Lloyd Edwards, George Howard, Bradley A. Maron, Thomas G. Brott, James F. Meschia, Florence X. Doo, Heng Huang
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Accurate characterization of carotid plaques is critical for stroke prevention in patients with carotid stenosis. We analyze 500 plaques from CREST-2, a multi-center clinical trial, to identify radiomics-based markers from B-mode ultrasound images linked with high-risk. We propose a new kernel-based additive model, combining coherence loss with group-sparse regularization for nonlinear classification. Group-wise additive effects of each feature group are visualized using partial dependence plots. Results indicate our method accurately and interpretably assesses plaques, revealing a strong association between plaque texture and clinical risk.